Cal-Os/Cal-Os Plus D/Cal-Os Chew Overdosage

Cal-Os Plus D: Hypercalcemia may occur when large doses of calcium are administered to patients with chronic renal failure. Mild hypercalcemia may exhibit as nausea, vomiting, anorexia, or constipation, with mental changes such as stupor, delirium, coma, or confusion. Mild hypercalcemia is usually readily controlled by reducing calcium intake (e.g., decreasing the dose of or avoiding supplement Calcium); more severe hypercalcemia may require specific management (e.g., hemodialysis).
Acute or chronic administration of excessive doses of Cholecalciferol may lead to hypervitaminosis D manifested by hypercalcemia. Treatment of Vitamin D analog intoxication consists of withdrawal of both the drug and calcium supplements, maintenance of a low-calcium diet, administration of oral or IV fluids and, if needed, corticosteroids or other drugs, particularly calciuric diuretics (e.g., furosemide and ethacrynic acid) to decrease serum calcium concentration. Hemodialysis or peritoneal dialysis against a calcium free dialysate may also be used. If ingestion is recent, gastric lavage or emesis may prevent further absorption. If the drug has passed through the stomach, administration of mineral oil may promote fecal elimination.
Cal-Os Chew: Symptoms of hypercalcaemia include thirst, polyuria, anorexia, constipation, muscle weakness, fatigue, and confusion. In severe cases, there may be nausea and vomiting; cardiac arrhythmias may develop but are rare. Extreme hypercalcaemia may result in coma and death. Chronic hypercalcaemia can lead to interstitial nephritis and calcium renal calculi. Mild asymptomatic hypercalcemia is best corrected by increasing oral fluid intake. Patients with more severe hypercalcemia, and/or significant symptoms, need prompt treatment by physician.